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학술논문

Radiotherapy combined with immunotherapy could improve the immune infiltration of melanoma in mice and enhance the abscopal effect

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영문명
Radiotherapy combined with immunotherapy could improve the immune infiltration of melanoma in mice and enhance the abscopal effect
발행기관
대한방사선종양학회
저자명
Yufeng Zheng Xue Liu Na Li Aimei Zhao Zhiqiang Sun Meihua Wang Judong Luo
간행물 정보
『대한방사선종양학회지』제41권 제2호, 129~139쪽, 전체 11쪽
주제분류
의약학 > 종양학
파일형태
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발행일자
2023.06.30
4,120

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Purpose: To analyze the gene mutation, immune infiltration and tumor growth of primary tumor and distant tumor under different treatment modes. Materials and Methods: Twenty B16 murine melanoma cells were injected subcutaneously into the of both sides of the thigh, simulating a primary tumor and a secondary tumor impacted by the abscopal effect, respectively. They were divided into blank control group, immunotherapy group, radiotherapy group, and radiotherapy combined immunotherapy group. During this period, tumor volume was measured, and RNA sequencing was performed on tumor samples after the test. R software was used to analyze differentially expressed genes, functional enrichment, and immune infiltration. Results: We found that any treatment mode could cause changes in differentially expressed genes, especially the combination treatment. The different therapeutic effects might be caused by gene expression. In addition, the proportions of infiltrating immune cells in the irradiated and abscopal tumors were different. In the combination treatment group, T-cell infiltration in the irradiated site was the most obvious. In the immunotherapy group, CD8+ T-cell infiltration in the abscopal tumor site was obvious, but immunotherapy alone might have a poor prognosis. Whether the irradiated or abscopal tumor was evaluated, radiotherapy combined with anti-programmed cell death protein 1 (anti-PD-1) therapy produced the most obvious tumor control and might have a positive impact on prognosis. Conclusion: Combination therapy not only improves the immune microenvironment but may also have a positive impact on prognosis.

목차

Introduction
Materials and Methods
Results
Discussion and Conclusion
Statement of Ethics
Conflict of Interest
Funding
Author Contributions
Data Availability Statement
Supplementary Materials
References

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APA

Yufeng Zheng,Xue Liu,Na Li,Aimei Zhao,Zhiqiang Sun,Meihua Wang,Judong Luo. (2023).Radiotherapy combined with immunotherapy could improve the immune infiltration of melanoma in mice and enhance the abscopal effect. 대한방사선종양학회지, 41 (2), 129-139

MLA

Yufeng Zheng,Xue Liu,Na Li,Aimei Zhao,Zhiqiang Sun,Meihua Wang,Judong Luo. "Radiotherapy combined with immunotherapy could improve the immune infiltration of melanoma in mice and enhance the abscopal effect." 대한방사선종양학회지, 41.2(2023): 129-139

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