Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 4: Liver and locally recurrent rectal cancer

• 발행기관: 대한방사선종양학회
• 저자명: Hwa Kyung Byun Gyu Sang Yoo Soo-Yoon Sung Jin-Ho Song Byoung Hyuck Kim Yoo-Kang Kwak Yeon Joo Kim Yeon-Sil Kim Kyung Su Kim
• 간행물 정보: 『대한방사선종양학회지』제42권 제4호, 247~256쪽, 전체 10쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

In this paper, we review the use of hypofractionated radiotherapy for gastrointestinal malignancies, focusing on primary and metastatic liver cancer, and recurrent rectal cancer. Technological advancements in radiotherapy have facilitated the direct delivery of high-dose radiation to tumors, while limiting normal tissue exposure, supporting the use of hypofractionation. Hypofractionated radiotherapy is particularly effective for primary and metastatic liver cancer where high-dose irradiation is crucial to achieve effective local control. For recurrent rectal cancer, the use of stereotactic body radiotherapy offers a promising approach for re-irradiation, balancing efficacy and safety in patients who have been administered previous pelvic radiotherapy and in whom salvage surgery is not applicable. Nevertheless, the potential for radiation-induced liver disease and gastrointestinal complications presents challenges when applying hypofractionation to gastrointestinal organs. Given the lack of universal consensus on hypofractionation regimens and the dose constraints for primary and metastatic liver cancer, as well as for recurrent rectal cancer, this review aims to facilitate clinical decision-making by pointing to potential regimens and dose constraints, underpinned by a comprehensive review of existing clinical studies and guidelines.

목차

Introduction

Liver KQ1: What is the Applicable Hypofractionated Radiotherapy Regimen for Primary and Metastatic Liver Cancer?

Liver KQ2: What are the Recommended Dose Constraints for Liver and Bowel Structures for Primary and Metastatic Liver Cancer?

Rectum KQ 1: What are the Appropriate Hypofractionated Radiotherapy Schedules and Indications for Re-irradiation in Cases of Recurrent Rectal Cancer?

Conclusion

Statement of Ethics

Conflict of Interest

Funding

Author Contributions

Data Availability Statement

References

키워드

Hepatocellular carcinoma Hypofractionation Liver neoplasms Rectal neoplasms Re-irradiation Radiosurgery