Outcomes of neoadjuvant chemoradiotherapy in T4 rectal cancer patients: a real-world single institution experience

• 발행기관: 대한방사선종양학회
• 저자명: Reza Ghalehtaki Kasra Kolahdouzan Guglielmo Niccolò Piozzi Saeid Rezaei Zoha Shaka Nima Mousavi Darzikolaee Reyhaneh Bayani Behnam Behboudi Mahdi Aghili Felipe Couñago Azadeh Sharifian Farzaneh Bagheri Reza Nazari Naeim Nabian Mohammad Babaei Mohsen Ahmadi Tafti Mohammadsadegh Fazeli Farshid Farhan
• 간행물 정보: 『대한방사선종양학회지』제42권 제4호, 273~280쪽, 전체 8쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

Purpose: Treatment outcomes of locally advanced rectal cancer have improved significantly in recent decades. This retrospective study aimed to assess the efficacy of neoadjuvant chemoradiotherapy (nCRT) followed by surgery in patients with T4 rectal cancer and the different outcomes between T4a and T4b patients. Materials and Methods: A total of 60 clinically T4 rectal cancer patients who underwent nCRT were included in the analysis. Patient characteristics, treatment regimens, down-staging rates, pathological response, and overall survival (OS) were evaluated. Results: Both T4a and T4b patients experienced down-staging following nCRT (36.6% and 6.2% respectively; p = 0.021). T4a patients exhibited a higher rate of pathological complete response (pCR) than T4b patients (13.3% in T4a vs. 0% in T4b; p = 0.122). After a median follow-up of 36 months, the OS and recurrence-free survival (RFS) of T4a patients were significantly higher compared to T4b patients (hazard ratio [HR] = 2.52, 95% confidence interval [CI] 1.05-6.05, p = 0.038 for OS; HR = 2.32, 95% CI 1.09-4.92, p = 0.025 for RFS). Conclusion: This study provides valuable insights into the effectiveness of nCRT in T4 rectal cancer patients. Although down-staging was observed in both T4a and T4b subgroups, achieving a pCR remains a challenge, particularly in T4b patients. Further research is needed to optimize treatment strategies and enhance pCR rates in T4 rectal cancer patients to improve oncologic outcomes.

목차

Introduction

Materials and Methods

Results

Discussion and Conclusion

Statement of Ethics

Conflict of Interest

Funding

Author Contributions

Data Availability Statement

References

키워드

Rectal cancer Radiation therapy Chemotherapy Neoadjuvant treatment