Research progress and treatment of radiation enteritis and gut microbiota

• 영문명: Research progress and treatment of radiation enteritis and gut microbiota
• 발행기관: 대한방사선종양학회
• 저자명: Huiwen Ren Qi Wu Zhiqiang Sun Mingming Fang Jun Liu Judong Luo
• 간행물 정보: 『대한방사선종양학회지』제41권 제2호, 61~68쪽, 전체 8쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2023.06.30

영문 초록

Radiation enteritis is a kind of intestinal radiation injury in patients with pelvic and retroperitoneal malignancies after radiotherapy, and its occurrence and development process are very complicated. At present, studies have confirmed that intestinal microecological imbalance is an important factor in the formation of this disease. Abdominal radiation causes changes in the composition of the flora and a decrease in its diversity, which is mainly manifested by a decrease in beneficial bacterial species such as Lactobacilli and Bifidobacteria. Intestinal dysbacteriosis aggravates radiation enteritis, weakens the function of the intestinal epithelial barrier, and promotes the expression of inflammatory factors, thereby aggravating the occurrence of enteritis. Given the role of the microbiome in radiation enteritis, we suggest that the gut microbiota may be a potential biomarker for the disease. Treatment methods such as probiotics, antibiotics, and fecal microbiota transplantation are ways to correct the microbiota and may be an effective way to prevent and treat radiation enteritis. Based on a review of the relevant literature, this paper reviews the mechanism and treatment of intestinal microbes in radiation enteritis.

목차

Introduction

Definition and Role of Gut Microbiota

Definition of Radiation Enteritis and Pathophysiologic Changes

How Radiation Enteritis Affects Gut Microbiota

Radiation Enteritis Therapy

Conclusion

Statement of Ethics

Conflict of Interest

Funding

Author Contributions

Data Availability Statement

References

키워드

Gut microflora Radiation enteritis Beneficial bacteria