Spontaneous pulmonary alveolar proteinosis in a C57BL/6 mouse: Case report

• 영문명: Spontaneous pulmonary alveolar proteinosis in a C57BL/6 mouse: Case report
• 발행기관: 한국예방수의학회
• 저자명: Warisraporn Tangchang Eun-Sang Cho Won Kee Yoon Hyo-Jung Kwon Hwa-Young Son
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.47, No.2, 102~104쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.06.30

영문 초록

This case report describes the pathological features of pulmonary alveolar proteinosis(PAP) in mouse. Grossly, multiple irregular yellow-grey patches were observed on the lung surface of a C57BL/6 mouse. Histopathologically, the alveolar walls were thickened by type II cell hyperplasia and cellular infiltrates, and the bronchioles and alveolar lumens were filled with amorphous eosinophilic lipoproteinaceous material. This material was positive for Periodic acid-Schiff stain. Gomori methenamine silver staining was negative. Immunohistochemical staining showed that cells in the alveolar wall and lumen were positive for surfactant protein B, chitinase-like protein-3, and CD68. As a result, PAP was diagnosed. This is a rare case of spontaneous PAP in mice, and we report the histopathological characteristics along with the literature.

키워드

Mouse Pulmonary alveolar proteinosis Surfactant protein