학술논문
Hibiscus syriacus Leaves Upregulate p62/SQSTM1 through TLR4/p38, JNK, and NF-κB/Nrf2 Signaling Pathway in RAW264.7 Cells
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- 영문명
- Hibiscus syriacus Leaves Upregulate p62/SQSTM1 through TLR4/p38, JNK, and NF-κB/Nrf2 Signaling Pathway in RAW264.7 Cells
- 발행기관
- 한국자원식물학회
- 저자명
- 임승우 박광훈 최민영 권해연 정진부
- 간행물 정보
- 『한국자원식물학회지』제36권 제3호, 191~197쪽, 전체 7쪽
- 주제분류
- 농수해양 > 기타농수해양
- 파일형태
- 발행일자
- 2023.06.30
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국문 초록
영문 초록
Autophagy contributes to enhancing the immune system (innate and adaptive immune system) against foreign pathogens. Autophagy of macrophages is used as a major indicator for developing vaccine adjuvants to increase the adaptive immune response. In this study, HSL increased p62/SQSTM1 expression. Inhibition of TLR4, p38, JNK, and NF-κB blocked HSL-mediated increase of p62/SQSTM1. HSL activated p38, JNK, and NF-κB signaling, but HSL-mediated activation of p38, JNK, and NF-κB signaling was reversed by TLR4 inhibition. In addition, HSL increased Nrf2 expression, but HSL-mediated Nrf2 expression did not occur in the inhibition of TLR4, p38, JNK, and NF-κB. Taken together, it is believed that HSL-mediated autophagy may be dependent on activating Nrf2 expression via TLR4-dependent activation of p38, JNK, and NF-κB in macrophages.
목차
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
Conflicts of Interest
References
해당간행물 수록 논문
- Hibiscus syriacus Leaves Upregulate p62/SQSTM1 through TLR4/p38, JNK, and NF-κB/Nrf2 Signaling Pathway in RAW264.7 Cells
- A New Record for Invasive Alien Plant: Melilotus dentatus (Waldst. & Kit.) Desf. (Fabaceae) in Korea
- Evaluation of Stomatal Characteristics of Adaxial and Abaxial Side of Flag Leaves of Korean Wheat Cultivars
- Suppression of Migration and Invasion by Alnus hirsuta in Human Hepatocellular Carcinoma Cells
- Hepatoprotective Effect of Alnus japonica and Portulaca oleracea Complex on Alcohol-induced Liver Injury Mice Models by Anti-oxidation Activity
- Variation in Phenotypic Traits in Onion (Allium cepa L.) Germplasm Collections
- [Erratum] Potential of Lilium lancifolium in Alleviating Pain and Inflammation in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis
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