당뇨병 전단계에서 제2형 당뇨병으로의 전이에 고혈압 및 인슐린 저항성의 영향 분석

• 영문명: Hypertension and Insulin Resistance from Prediabetes to Type 2 Diabetes: A 10-Years South Korean Prospective Cohort Study
• 발행기관: 한국보건사회약료경영학회
• 저자명: 정주원 조윤 이한길 한은아
• 간행물 정보: 『한국보건사회약료경영학회지』제11권 제1호, 52~62쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.05.31

영문 초록

BACKGROUNDS There are many people with prediabetes. As prediabetes is a strong risk factor for Type 2 Diabetes and an opportunity to prevent Type 2 Diabetes, it is important to identify prediabetes with high risk of developing Type 2 Diabetes. The aim of this study is to examine whether hypertension or insulin resistance are valid transition factors to Type 2 Diabetes from prediabetes. METHODS 2265 middle-aged South Korean examinees with prediabetes in the Korean Genome and Epidemiology Studies (KoGES) during the follow-up period of 10 years. RESULTS During 8.24 person- years, we identified 469 incident Type 2 Diabetes cases (21%). The incidence of Type 2 Diabetes increased with hypertension or insulin resistance with the adjusted hazard ratios (HRs) of 1.595 (CI: 1.209-2.105) and 2.286 (1.761-2.968) respectively. Compared to those with hypertension (Adjusted HR, 1.342 [CI: 1.045-1.723]), those with hypertension and insulin resistance showed a larger HR (Adjusted HR, 2.593 [CI: 1.802-3.733]). CONCLUSION Middle-aged South Koreans with prediabetes who had hypertension or insulin resistance were especially high at risk of developing Type 2 Diabetes. Hypertension had an association with Type 2 Diabetes, whereas insulin resistance had a causal impact on East Asian populations to have Type 2 Diabetes.

목차

Introduction

Methods

Results

Discussion

Acknowledgements

Author Contributions

Conflict of interest

Data Availability

References

키워드

Prediabetes Type 2 Diabetes Hypertension Insulin resistance Korean Genome and Epidemiology Studies