전통적 고위험군을 제외한 인구집단에서의 간암 발생 분석

• 영문명: Occurrence of Liver Cancer in People without Traditional Risk Factors
• 발행기관: 대한임상노인의학회
• 저자명: 최준호 박주현 이재광 조경희
• 간행물 정보: 『대한임상노인의학회지』제24권 제1호, 41~47쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.04.30

영문 초록

Background: According to the 2019 National Cancer Registry Statistics in Korea, the age-standardized incidence of liver cancer ranked seventh among all types of cancer in Korea. We analyzed the factors associated with the population-wide occurrence of liver cancer, excluding traditional high-risk groups such as those with hepatitis B, hepatitis C, and liver cirrhosis. Methods: Among the 8,706,575 people who participated in the National Health Examination in 2009, the data for 7,254,458 people were selected and analyzed, excluding those with the traditional risk factors of hepatitis B, hepatitis C, and liver cirrhosis. The incidence of liver cancer during the 2009-2018 period and differences according to demographic factors, lifestyles, and metabolic comorbidities were analyzed. The hazard ratios (HRs) of liver cancer for these variables were analyzed by Cox regression analysis. Results: During the 10-year follow-up period, liver cancer occurred in 50,277 (0.69%) out of 7,254,458 cases. People aged 80 and above had the highest HR, 4.016 (95% confidence interval, 3.906-4.125, P＜.0001). The HRs of the groups with impaired fasting glucose and diabetes mellitus were 1.047 (1.007-1.087, P=.035) and 1.193 (1.160-1.227, P＜.0001), respectively. The lifestyle factors such as high-risk drinking (1.310, 1.260-1.361, P＜.0001) and current smoking (1.097, 1.066-1.129, P＜.0001) were positively associated with the occurrence of liver cancer. Conclusion: We identified the factors associated with the occurrence of liver cancer besides viral hepatitis and liver cirrhosis. The results indicate that public guidelines are needed to prevent liver cancer. Further prospective studies that include genetic factors and other omitted variables are required.

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키워드

Hepatocellular carcinoma Incidence of liver cancer Risk analysis