Effect of Testosterone Supplementation on Cognition in Elderly Men: A Systematic Meta-Analysis

• 영문명: Effect of Testosterone Supplementation on Cognition in Elderly Men: A Systematic Meta-Analysis
• 발행기관: 대한임상노인의학회
• 저자명: Seung Wan Hong Yoon Jeong Cho Jae Hyuck Lee Young Sung Suh Dae Hyun Kim
• 간행물 정보: 『대한임상노인의학회지』제24권 제1호, 24~33쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.04.30

영문 초록

Background: Cognitive function is an important issue in aging societies. Testosterone levels and cognitive function are known to be correlated; however, the clinical conclusions remain controversial. This study aimed to investigate whether testosterone supplementation improve cognitive function in adult men through a systematic meta-analysis. Methods: A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The PubMed, Cochrane Library, and Embase databases were searched. Literature search, study identification, and data extraction were performed between December 2019 and March 2021. Results: A total of 15 studies were included in the meta-analysis. The sample sizes of the selected studies varied from 11 to 493. There were no significant differences in cognitive speed (standardized mean difference [SMD]=−0.05; 95% confidence interval [CI], −0.26 to 0.16), immediate verbal memory function (SMD=0.07; 95% CI, −0.05 to 0.20), immediate visual memory function (SMD=−0.01; 95% CI, −0.15 to 0.13), working memory function (SMD=−0.04; 95% CI, −0.42 to 0.35), delayed memory function (SMD=−0.02; 95% CI, −0.14 to 0.10), executive function (SMD=0.03; 95% CI, −0.08 to 0.15), perception (SMD=−0.13; 95% CI, −0.37 to 0.11), cognitive inhibition (SMD=−0.13; 95% CI, −0.49 to 0.23), visual attention (SMD=−0.02; 95% CI, −0.16 to 0.11), and cognitive status scores (SMD=−0.02; 95% CI, −0.18 to 0.14). Conclusion: The findings of this study indicate that there is a lack of evidence that testosterone administration has an effect on preventing cognitive decline. Therefore, testosterone use to prevent cognitive decline may not be recommended.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

CONFLICT OF INTEREST

REFERENCES

키워드

Aging Cognition Hormone replacement therapy Testosterone