Subacute oral toxicity of Dendropanax morbiferus H.Lév leaf extracts in Sprague-Dawley rats

• 영문명: Subacute oral toxicity of Dendropanax morbiferus H.Lév leaf extracts in Sprague-Dawley rats
• 발행기관: 한국예방수의학회
• 저자명: Jiyong Park Chang-Soo Cho Jun-Ho Song Kwang Il Park Yeung Bae Jin Woo Hyun Kim Suk Kim Hu-Jang Lee
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.47, No.1, 13~18쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.03.30

영문 초록

This study examined the subacute oral toxicity of Dendropanax morbiferus H.Lév leaves hot-water extracts (DMWE) using male and female Spargue-Dawley rats. Rats were orally administered the DMWE at dose levels of 0, 250, 500, 1,000, and 2,000 mg/kg body weight (BW) for four weeks. For experimental period, clinical signs and the number of deaths were examined, and feed intake and BW of all experimental animals were measured once a week for four weeks. At the end of the experiment, blood samples were collected from all rats, and all animals were euthanized and autopsies were performed to collect major organs. No dead animals were found during the experimental period. In addition, no differences were found between control and DMWE-treated groups in feed intakes, BW changes, organ weights, clinical signs, hematological parameters, and serum biochemical parameters. The results of this study provided evidence that oral administration of DMWE at the dose of 2,000 mg/kg BW is safe in rats and may not exert severe toxic effects.

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키워드

Dendropanax morbiferus leaf subacute oral toxicity rats