상황버섯(Phellinus baumii) 균사체 액체배양 포스트바이오틱스의 면역자극활성

• 영문명: Immunostimulatory Activity of Postbiotics from Liquid Culture of Phellinus baumii Mycelium
• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: 김연숙 신현영 김훈 정은진 구자평 하은지 김가을에 정세빈 서형주 신광순 유광원
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』8권 2호, 92~102쪽, 전체 11쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2022.12.30

영문 초록

After liquid culture of Phellinus baumii (P. baumii) mycelium (LPBM) was prepared, LPBM was fractionated into A∼E fraction (A; hot-water extract of liquid culture including mycelia, B; crude polysaccharide of A, C; hot-water extract of mycelia, D; crude polysaccharide of C, and E; crude polysaccharide of culture broth) to evaluate for possibility as functional materials with immunostimulatory activity. In macrophage stimulatory activity, E fraction as postbiotics significantly increased secretion of NO and IL-12 from RAW 264.7 cells. Next, when the splenocytes of C3H/HeN mice were primary cultured, E fraction showed significantly mitogenic activity with enhancing mitogen-related cytokines (IFN-γ and TNF-α) production from splenocyte. E fraction also potently stimulated GM-CSF production from Peyer’s patch cells as well as Peyer’s patch-mediated bone marrow cell proliferation. In addition, the immunostimularoy E fraction contained neutral sugar (73.8%), uronic acid (10.6%), protein (7.8%), and polyphenol (7.5%), and mainly consisted of glucose (39.1%), galactose (21.7%), mannose (11.1%), galacturonic acid (9.9%), and arabinose (8.9%) as component sugars. In conclusion, it was demonstrated that postbiotics including exopolysaccharide fractionated from liquid culture of the P. baumii mycelium could enhanced immunostimulatory activity.

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키워드

postbiotics Phellinus baumii mycelium liquid culture exopolysaccharide immunostimulatory activity