COVID-19에 돌파감염된 노인 환자에서 백신접종 효용성에 대한 고찰

• 영문명: A Study on The Efficacy of Vaccination in Elderly Patients with Breakthrough COVID-19 Infection
• 발행기관: 대한임상노인의학회
• 저자명: 최수복 최시온 하철민 이형주 김총명
• 간행물 정보: 『대한임상노인의학회지』제23권 제2호, 115~122쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.12.31

영문 초록

Background: Old age is one of the risk factors for COVID-19, and previous studies, mainly in the U.S., have shown that the COVID-19 vaccine has obvious efficacy in reducing the morbidity and progression to severe disease. This study focused on whether vaccination affects the disease progression in elderly COVID-19 patients in South Korea. Methods: We divided COVID-19 patients over 65 years of age hospitalized at a single medical institution into a vaccinated group and an unvaccinated group, a the progression group and the improvement group, and cross-analyzed them with a chi-square test, and then obtained the odds ratio by binary logistic regression analysis. Results: Of the total patients, 14 (4.3%) in the vaccinated group (n=323) and 29 (23.4%) in the unvaccinated group (n=124) were in the progression group, showing a significant difference (P=0.000). Subsequent binary logistic regression analysis showed that the odds ratio was 0.112 (P=0.000), indicating that vaccination had a significant effect on reducing the progression to severe disease. Conclusion: The COVID-19 vaccine is effective in reducing progression to severe disease in older patients with breakthrough infection, and vaccination is recommended for elderly patients.

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키워드

Aged COVID-19 Disease progression Vaccination