Effects of dietary acetaminophen, vitamin C and thioctic acid supplements on stress responses in mice vaccinated with foot-and-mouth disease vaccine

• 영문명: Effects of dietary acetaminophen, vitamin C and thioctic acid supplements on stress responses in mice vaccinated with foot-and-mouth disease vaccine
• 발행기관: 한국예방수의학회
• 저자명: Jin-Kyoung Kim Song-Ee Son Won-Seok Chae Suk Kim Hu-Jang Lee
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.46, No.3, 173~177쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.09.30

영문 초록

This study evaluated the effect of a combination of acetaminophen (AAP), vitamin C (VC) and thioctic acid (TA) on reducing serum cortisol concentrations in mice with foot-and-mouth disease (FMD) vaccination. For 5 days from 3 days before FMD vaccination to 2 days after vaccination, mice were orally administered with AAP 600 mg/kg feed (n=25, AAPT), combination of AAP 600 mg and VC 200 mg per kg feed (n=25, AVCT) and combination of AAP 600 mg, VC 200 mg and TA 20 mg per kg feed (n=25, AVTT), respectively. From day 1 to day 7 after FMD vaccination, the cortisol concentration of all groups treated with the drug was significantly decreased compared to that of the positive control group with FMD vaccination (p<0.05). In conclusion, the combined treatment of AAP, VC and TA was the most effective in relieving stress from FMD vaccination compared to the single treatment.

키워드

FMD vaccination stress serum cortisol concentration mice