학술논문
The SARS-CoV-2 Delta variant spike protein facilitates cell-cell fusion
이용수 0
- 영문명
- The SARS-CoV-2 Delta variant spike protein facilitates cell-cell fusion
- 발행기관
- 한국예방수의학회
- 저자명
- Jinman Kim Seokin Kim Jung-Eun Park
- 간행물 정보
- 『Journal of Preventive Veterinary Medicine』Vol.46, No.3, 149~154쪽, 전체 6쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2022.09.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates virus entry by binding to the host cell receptor, human angiotensin converting enzyme 2 (hACE2), and catalyzing virus-host membrane fusion. The S protein also mediates cell-cell fusion, potentially allowing the virus to spread virion-independently. Here, we compared the fusogenicity of SARS-CoV-2 variant S proteins using a cell-cell fusion assay. In cells overexpressing hACE2, cell-cell fusion ability of all tested SARS-CoV-2 variants was similar to that of the Wuhan-Hu-1 strain. However, in cells with endogenous hACE2, SARS-CoV-2 variants, especially the Delta variant, stimulated significantly greater cell-cell fusion than the original strain. Our results showed that the Delta variant S protein is highly fusogenic and can spread rapidly by utilizing small amounts of hACE2.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
해당간행물 수록 논문
- Case report of diseases in psittacine birds, South Korea, 2012-2021
- The SARS-CoV-2 Delta variant spike protein facilitates cell-cell fusion
- Comparison of stunning methods on consciousness in pigs during slaughter
- Virucidal efficacy of gaseous chlorine dioxide against surface-dried Adenovirus and Herpesvirus
- Immunogenicity of a bacterial ghost delivered dengue virus serotype 2 envelope protein domain III followed by an intramuscular protein boosting strategy in mice model
- Modification of carboxy-terminal amino acid composition to enhance expression of foot-and-mouth disease virus VP4 protein
- Optimization of residual analysis of streptomycin and dihydrostreptomycin in swine plasma, urine and tissues using LC-MS/MS
- Molecular characterization of antimicrobial-resistant Citrobacter freundii isolated from pet turtles in Korea
- Hair plucking as an alternative non-invasive sampling method for the detection of African swine fever virus
- Effects of dietary acetaminophen, vitamin C and thioctic acid supplements on stress responses in mice vaccinated with foot-and-mouth disease vaccine
- Occurrence of CTX-M-producing Escherichia coli from in broilers with colibacillosis
- Journal of Preventive Veterinary Medicine Vol.46, No.3 목차
참고문헌
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!