Reuterin 및 이의 구조적 특징과 생물학적 활성에 대한 고찰

• 영문명: Review on the Structural Features and Biological Activities of Reuterin
• 발행기관: 대한약학회
• 저자명: 정유라(Yu Ra Jeong) 김예은(Ye Eun Kim) 이상협(Sang Hyup Lee)
• 간행물 정보: 『약학회지』제66권 제4호(2022년), 169~174쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.08.30

영문 초록

Reuterin, one of the low-molecular organic compounds, contains an aldehyde and alcohol group with three carbons. It also possesses a certain degree of complexity in chemical structure because of the presence of aldehyde group. In an aqueous solution of reuterin, monomeric, hydrate, and dimeric forms coexist in equilibrium. Reuterin has diverse biological activities, including antibacterial, anticancer, antiinflammatory, and antifungal activities. Specifically, it displays stronger antibacterial activities and lower toxicities than the existing antimicrobial agents such as glutaraldehyde. Due to the beneficial biological attributes, reuterin can be a potential candidate for novel functional compounds in the food and pharmaceutical industry. Preparation methods for reuterin include biochemical conversion and chemical synthesis. Biochemical conversion approach employs bioconversion using glycerol and Lactobacillus reuteri and chemical synthesis utilizes acrolein or 1,2,4-butanetriol as a starting material. However, despite its exceptional biological activities, the mechanism of action is obscure. Collectively, reuterin has substantial potential as a functional compound in food and pharmaceutical domain.

목차

서 론(Introduction)

Reuterin의 효능 및 작용 기작

Reuterin의 합성 및 구조적 특징

결 론(Conclusion)

References

키워드

Reuterin 3-Hydroxypropionaldehyde Antimicrobial Antibacterial Disinfectant