Melatonin and Alzheimer’s Disease: A Mini-Review

• 발행기관: 대한노인정신의학회
• 저자명: Yoo Hyun Um Hyun Kook Lim
• 간행물 정보: 『노인정신의학』노인정신의학 제26권 제1호, 8~11쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2022.04.30

영문 초록

Melatonin is a hormone with neuroregulatory, antioxidant and anti-inflammatory properties. Its benevolent effects on Alzheimer’s disease (AD) has been replicated in both animal models and clinical studies. Melatonin was effective in deterring the toxic effects of amyloid beta (Aβ) and reducing tau phosphorylation. Conflicting results exist for the clinical effectiveness of melatonin administration in AD patients. The positive effects of melatonin in AD have mainly been viewed from its role in sleep and circadian rhythm. Several limitations exist in the previous research on the relationship between melatonin and AD. Future research should focus on sharpening methodology, and adopting more expanded, multi-faceted approach, with consideration for melatonin’s antioxidant and anti-inflammatory properties.

목차

Introduction

Melatonin and Its Association with AD in Animal Models

Clinical Implications of Melatonin and

Its Association with AD

Limitations and Future Directions with Regard to the Research on the Relationship between Melatonin and AD

Conclusion

REFERENCES

키워드

Alzheimer Disease Melatonin Cognition