알츠하이머병 환자에서 맥락망총과 망상아형과의 연관성

• 영문명: Choroid Plexus and Its Association of Subtypes of Delusion in Patient With Alzheimer’s Disease
• 발행기관: 대한노인정신의학회
• 저자명: 손성미(Sung-Mi Son) 이영민(Young-Min Lee) 박제민(Je-Min Park) 이병대(Byung-Dae Lee) 문은수(Eunsoo Moon) 정희정(Hee-Jeong Jeong) 서화규(Hwagyu Suh) 김경원(Kyungwon Kim) 김학진(Hak-Jin Kim) 박경준(Kyongjune Park) 최경운(Kyung-Un Choi)
• 간행물 정보: 『노인정신의학』노인정신의학 제26권 제1호, 18~22쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2022.04.30

영문 초록

Objective: This study examined the volume of choroid plexus across AD without delusion (AD-D), AD with paranoid delusion (AD+PD), and AD with misidentification delusion (AD+MD). Methods: This is a hospital based cross-sectional study of patients with AD. The main outcome measure is the volume of choroid plexus that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance (ANCOVA) was conducted to compare the differences on the volume of choroid plexus across AD-D, AD+PD, and AD+MD after controlling demographics. Results: There was no volume difference in the both choroid plexus between AD-D and AD+D. However, the volumes of both choroid plexus were significantly reduced in AD+MD compared to AD+PD. Conclusion: Our study demonstrates that AD+MD has significantly reduced volumes of choroid plexus compared to AD+PD. These findings suggest that AD+MD and AD+PD may have different pathophysiological mechanisms related to neuroimmune responses in the choroid plexus.

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키워드

Choroid plexus Alzheimer’s disease Misidentification delusion