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• 영문명: Verification of the Effect of Lemon Balm Extract on Triglyceride Control According to the Extraction Solvent
• 발행기관: 한국자원식물학회
• 저자명: 김지연(Ji Youn Kim) 김경곤(Kyoung Kon Kim) 이혜림(Hye Rim Lee) 김대중(Dae Jung Kim) 김태우(Tae Woo Kim)
• 간행물 정보: 『한국자원식물학회지』제35권 제2호, 372~379쪽, 전체 8쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2022.04.30

영문 초록

This study investigated the effect of lemon balm (Melissa officinalis) extract on improving blood triglycerides according to the extraction solvent using 3T3-L1 cells. Lemon balm was extracted with water (MOW100), 70% ethanol (MOE70), 50% ethanol (MOE50), and 30% ethanol (MOE30). To verify its efficacy on improving blood triglycerides, cell viability, lipid accumulation, triglyceride (TG) content, and expressions of protein kinase A (PKA), adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), perilipin, and CGI-58 proteins were evaluated. Cytotoxicity was not evident up to an extract concentration of 1 ㎎/mL. Lipid accumulation and TG content were decreased in a concentration- dependent manner compared to their levels in the control group. When the MOW100 extract was applied at a concentration of 0.2 ㎎/mL, an inhibitory effect was evident, with lipid accumulation inhibited by 21.3% and TG content reduced by 32.7%. PKA phosphorylation and ATGL HSL and CGI-58 levels were increased. The data indicate that lemon balm extract obtained using water is more efficacious than extracted with ethanol. The aqueous extract shows potential in triglyceride control through lipolysis and lowering triglyceride levels.

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키워드

ATGL HSL Melissa officinalis PKA Triglyceride