소나무 담쟁이덩굴(Parthenocissus tricuspidata (Siebold & Zucc.) Planch) 줄기 추출물의 항비만 효과

• 영문명: Anti-Obesity Effect of Parthenocissus tricuspidata (Siebold & Zucc.) Planch Stem Extracts
• 발행기관: 한국자원식물학회
• 저자명: 여주호(Joo Ho Yeo) 유주형(Yu Ju Hyeong) 최민영(Min Yeong Choi) 이재원(Jae Won Lee) 금나경(Na Gyeong Geum) 안미연(Mi-Yun An) 정철의(Chuleui Jung) 정진부(Jin Boo Jeong)
• 간행물 정보: 『한국자원식물학회지』제35권 제2호, 380~384쪽, 전체 5쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2022.04.30

영문 초록

In this study, we investigated in vitro anti-obesity activity of Parthenocissus tricuspidata (Siebold & Zucc.) Planch stem (PTS) in mouse adipocytes 3T3-L1 cells. PTS inhibited lipid accumulation and reduced the expression level of the proteins such as C/EBPα, PPARγ and FABP4 associated with adipogenesis in 3T3-L1 cells. In addition, PTS increased lipolysis-related protein expression such as p-AMPK, ATGL and p-HSL, and reduced perilipin-1 in 3T3-L1 cells. Taken together, PTS may have anti-obesity activity through inhibiting adipogenesis and inducing lipid lipolysis in adipocytes. Based on these results, PTS is expected to be used as a potential functional agent for anti-obesity.

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키워드

Adipocytes Anti-obesity activity Parthenocissus tricuspidata (Siebold & Zucc.) Planch