스피페론에 의한 멜라닌 생성에 미치는 칼슘-활성화 염소통로의 역할

• 영문명: Role of Ca2+-activated Cl−Channels in the Spiperone-mediated Melanogenesis
• 발행기관: 대한약학회
• 저자명: 이용수(Yong Soo Lee)
• 간행물 정보: 『약학회지』제65권 제5호(2021년), 349~354쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

The molecular mechanism underlying the stimulation of melanin synthesis by the antipsychotic drug spiperone (SP) was investigated in B16 melanoma cells. SP increased the melanin content and intracellular Ca2+ ion concentration in a dose-dependent manner. Treatment with bis-(o-aminophenoxy)-ethane-N,N,N ,N -tetraacetic acid/acetoxymethyl ester, an intracellular Ca2+ chelator, significantly inhibited SP-induced melanin synthesis. SP induced considerable Cl− efflux, which was inhibited by niflumic acid and flufenamic acid, known Ca2+-activated Cl− channel (CaCC) blockers. Furthermore, these CaCC blockers significantly inhibited SP-induced melanin synthesis. Thus, these results suggest that CaCCs may play an important role in SP-induced melanin synthesis in melanoma cells.

목차

서론(Introduction)

결과및고찰(Results and Discussion)

결론(Conclusion)

감사의말씀(Acknowledgment)

Conflict of Interest

References

키워드

Spiperone Melanin synthesis Ca2+ signal Ca2+-activated Cl− channel B16 melanoma cell