Strain, Age, and Gender Differences in Response to Lipopolysaccharide (LPS) Animal Model of Sepsis in Mice

• 발행기관: 대한약학회
• 저자명: Ivan Gahima Eric Twizeyimana Edson LuckGonzales Chilly Gay Remonde Se Jin Jeon Chan Young Shin
• 간행물 정보: 『약학회지』제65권 제1호(2021년), 17~22쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.02.28

영문 초록

Sepsis is an excessive and irregular host response against existing infection, wherein pathogen invasion is primarily responsible for the resulting damage. However, sepsis-related damage is substantially caused by excessive uncontrolled host response. The purpose of this study was to investigate the differences in immune response based on the strain, age, and sex of mice by examining the survival rate and latency following immune challenge. The results showed that there was no significant difference between strains (ICR and C57BL6) following lipopolysaccharide (LPS) treatment. Adolescent male mice (8 weeks old) had a higher survival rate and longer latency to death compared to those of adult mice (13 weeks old) following LPS treatment. Moreover, the onset of death in adolescent mice occurred substantially later compared to that in adult mice. Females displayed longer latency to death and higher survival rates compared to their male counterparts following immune challenge. Thus, the differences in survival rate and latency between young and adult mice and between male and female might contribute to age- and sex-specific adaptive host immunity, respectively. Our findings highlight the importance of considering the age, sex and strain of animals in experimental models of sepsis and provide a rationale to evaluate susceptibility in specific designs of sepsis immunotherapy. The clinical relevance of this study awaits further studies.

목차

Introduction

Methods

Results and Discussion

Conclusion

Acknowledgments

Conflict of Interest

References

키워드

Lipopolysaccharides Sepsis Survivability Gender Age