Analyses of Organic Acids and Phenolic Compounds in Columbia Coffee Bean in Roasting Process

• 영문명: Analyses of Organic Acids and Phenolic Compounds in Columbia Coffee Bean in Roasting Process
• 발행기관: 한국자원식물학회
• 저자명: Park, Jongsun Kim, Yongsung Yeon, Jihun Woo, Jongwook Seo, Youmi Mun, Jeong-Yun Choi, Ji-Soo Park, Min-Jeong Im, Jong-Yun Jang, Tae-Won Park, Jae-Ho
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2018년도 춘계학술발표회, 88~88쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2018.04.30

영문 초록

Abeliophyllum distichum is a medicinal plant used in regional traditional medicine to relieve pain in inflammatory processes. In this study, anti-inflammatory effects of Abeliophyllum distichum stem (ADS) ethyl acetate extract were examined. Furthermore, possible molecular mechanisms of the anti-inflammatory effects were dissected. The anti-inflammatory activity was investigated by inhibition of lipopolysaccharide (LPS) induced pro-inflammatory cytokine production in murine macrophage-like cell line Raw264.7 cells and human microglial cell line BV2 cells. The measurement of the induced pro-inflammatory cytokine levels were carried out by ELISA. The phosphorylation of ERK1/2, JNK, and MAPK, and the nuclear expression of nuclear factor $NF-{\kappa}B$ p65 were investigated by Western blot analysis. The extract of ADS significantly decreased the production of pro-inflammatory cytokines. In addition, the extract suppressed the phosphorylation of ERK1/2, JNK, and p38 MAPK, and the nuclear translocation of $NF-{\kappa}B$ p65 in activated cells. Our findings provide evidence for the popular use of Abeliophylli distichum in inflammation around Goesan region and also suggest that the stem extract has potential therapeutic benefits against several inflammatory diseases.

키워드

Abeliophyllum distichum flower Inflammation LPS