Anti-adipogenic Effect of Chlorogenic Acid in 3T3-L1 Adipocytes

• 영문명: Anti-adipogenic Effect of Chlorogenic Acid in 3T3-L1 Adipocytes
• 발행기관: 한국자원식물학회
• 저자명: Park, Se-Eun Choi, Jun-Hui Lee, Hyo-Jeong Seo, Kyoungsun Kim, Seung
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2018년도 춘계학술발표회, 80~80쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2018.04.30

영문 초록

The present study was investigated on in vitro anti-obesity effect of 4-hydroxybenzyl alcohol from Cudrania tricuspidata. We isolated various compounds from Cudrania tricuspidata. Among these compounds, anti-obesity effects of 4-hydroxybenzyl alcohol was examined by lipase activity assay, cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase type IV (PDE4) activity assay, and citrate synthase activity assay. 4-hydroxybenzyl alcohol and Cudrania tricuspidata extracts inhibited the enzymatic activities of lipase, PDE4, and citrate synthase. Lipase is known to mediate the hydrolysis of triacylglycerol in adipose tissue and cholesterol esters in other tissue or cells. Also, PDE4 hydrolyses cAMP, a crucial secondary messenger for in metabolic pathways including glucose and lipid metabolism, lipolysis, and thermogenic function. 4-hydroxybenzyl alcohol and Cudrania tricuspidata extracts induced the inhibitory effect against each enzymatic activity on several specific substrates as observed by detection at 405 or 412 nm. These findings might be attributable to the inhibition of adipogenesis, and partial prevention of obesity. In conclusion, these results show that 4-hydroxybenzyl alcohol and Cudrania tricuspidata may be a critical candidate as a natural anti-obesity source.

키워드

Cudrania tricuspidata 4-hydroxybenzyl alcohol Anti-obesity effect Adipogenesis