A Study on Antimicrobial Activity of Lysimachia clethroides Duby Root Extracts against Methicillin-resistant Staphylococcus aureus

• 발행기관: 한국자원식물학회
• 저자명: Dae Ki Joung Dong Yeul Kwon Dong Won Shin
• 간행물 정보: 『한국자원식물학회지』제31권 제6호, 719~724쪽, 전체 6쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2018.12.30

영문 초록

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for a number of infections inhumans that are difficult to treat, and as a result, is a substantial contributor to morbidity and mortality. In the present study,in search of natural products capable of inhibiting this multidrug-resistant bacterium, we investigated the antimicrobialactivity of Lysimachia clethroides Duby root. The antibacterial activities of EtOH extract of Lysimachia clethroides Dubyroot and its n-hexane, EtOAc, n-BuOH and water fractions were evaluated against 15 strains of methicillin-resistantstaphylococcus aureus (MRSA) and 1 standard methicillin-susceptible S. aureus (MSSA) strain by using the minimalinhibitory concentrations (MICs) assay, colorimetric assay using MTT test, checkerboard dilution test. Antimicrobialactivity of n-hexane fraction of Lysimachia clethroides Duby root was remarkable. Against the 16 strains, the minimuminhibitory concentrations (MICs) were in the range of 31.25–62.5 ㎍/㎖ and FICI values for n-hexane fraction ofLysimachia clethroides Duby root+AM and n-hexane fraction of Lysimachia clethroides Duby root+OX were checkerboardmethod performed using the MRSA, MSSA and one clinical isolate strains via MICI 0.12-1 and 0.25-0.75, showing theincrease of synergistic effect. When combined together, these antibiotic effects were dramatically increased. These effectivecombinations could be new promising agents in the management of MRSA.

목차

Introduction

Materials and Methods

Results

Discussion

Acknowledgements

References

키워드

Antimicrobial Lysimachia clethroides Duby Methicillin-resistant staphylococcus aureus (MRSA) Synergism