Dimethylnitrosamine으로 유발된 생쥐 간섬유화에 대한 풋귤 추출물의 억제 효과

• 영문명: Suppressive Effects of Premature Citrus unshiu Extract on Dimethylnitrosamine-induced Hepatic Fibrosis in Mice
• 발행기관: 대한약학회
• 저자명: 한상철(Sang-Chul Han) 윤지현(Ji-Hyun Yun) 윤원종(Weon-Jong Yoon) 윤선화(Seon-A Yoon) 강희경(Hee-Kyoung Kang) 유은숙(Eun-Sook Yoo)
• 간행물 정보: 『약학회지』제64권 제5호(2020년), 377~386쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2020.10.30

영문 초록

Hepatic fibrosis is a wound healing process of the liver, which is characterized by overproduction and accumulation of extracellular matrix. Hepatic fibrosis occurs when chronic inflammation causes a deposition of scar tissue. Dimethylnitrosamine (DMN) is a potent liver toxin that can lead to fibrosis of the liver. DMN causes massive hepatocyte damage, cell death by necrosis or apoptosis and liver tissue distribution. Citrus unshiu, which is known to contain several flavonoids, has pharmacological effects on anti-oxidative, anti-cancer, anti-microviral and anti-inflammation activity. Therefore, we investigated the effect of premature C. unshiu and fermented premature C. unshiu extract on DMN-induced hepatic fibrosis mouse model. Here, we show that administration of premature C. unshiu and fermented premature C. unshiu reduces the generation of triglyceride, alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA) and cytochrome P450 2E1 (CYP2E1) in mouse serum. Also, the extract reduced the mRNA expression of glutathione S-transferases (GSTs), Heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and increased inflammatory factors such as IL-6, COX-2 and iNOS. These results suggest that premature C. unshiu has anti-hepatic fibrosis activity by regulating metabolic detoxification pathways such as cytochrome P450s and GSTs.

목차

서 론(Introduction)

실험 방법(Experimental Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

References

키워드

hepatic fibrosis dimethylnitrosamine Citrus unshiu cytochrome P450s glutathione S-transferases