TRPV1에 의한 멜라닌 생성에 미치는 산화질소의 역할

• 영문명: Role of Nitric Oxide in the TRPV1-mediated Melanogenesis
• 발행기관: 대한약학회
• 저자명: 이용수(Yong Soo Lee)
• 간행물 정보: 『약학회지』제64권 제5호(2020년), 387~393쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2020.10.30

영문 초록

We investigated the possible role of transient receptor potential vanilloid 1 (TRPV1) in melanogenesis in B16 melanoma cells. Capsaicin (CAP), a TRPV1 agonist, increased production of melanin and nitric oxide (NO) in a dosedependent manner, which was inhibited by capsazepine (CPZ), a TRPV1 antagonist. The CAP-induced melanin synthesis was blocked by L-NAME and cPTIO, an inhibitor of NO synthase and a NO scavenger, respectively. CAP increased intracellular Ca²⁺ concentration and BAPTA/AM, an intracellular Ca²⁺ chelator, inhibited the CAP-induced production of NO and melanin. These results suggest that TRPV1 may stimulate melanogenesis through intracellular Ca²⁺-mediated production of NO.

목차

서 론(Introduction)

실험 방법(Experimental Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

References

키워드

TRPV1 melanogenesis capsaicin nitric oxide B16 melanoma cell