학술논문
Efficacy and Safety of Lacosamide in Adolescents with Lennox-Gastaut Syndrome
이용수 2
- 영문명
- 발행기관
- 대한소아신경학회
- 저자명
- Han Som Choi Se Hee Kim Hoon-Chul Kang Joon Soo Lee Heung Dong Kim
- 간행물 정보
- 『Annals of Child Neurology(구 대한소아신경학회지)』Annals of Child Neurology vol.28 no.3, 93~99쪽, 전체 7쪽
- 주제분류
- 의약학 > 소아과학
- 파일형태
- 발행일자
- 2020.07.31
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Purpose: We aimed to assess the efficacy and safety of lacosamide in Korean adolescents with Lennox-Gastaut syndrome (LGS), especially in those who concomitantly used other sodium channel blockers (SCBs).
Methods: We retrospectively reviewed the medical records of adolescents with LGS who initiated lacosamide from ages 16 to 18. The efficacy of lacosamide was evaluated by seizure frequency before and after lacosamide trial. Safety was assessed by lacosamide-related adverse events, consequent dosage titration, and titration effects. We compared the efficacy and safety of lacosamide according to concomitant use of other SCBs.
Results: In 26 eligible adolescents with LGS, the median age of seizure onset was 2.0 years, and the median age of lacosamide initiation was 17.1 years. At the time of lacosamide initiation, the median number of concomitant antiepileptic drugs was 4, and 23 patients (88%) had tried dietary, surgical, or neuromodulatory therapies. Patients were on lacosamide for a median of 13.5 months with a median maximal dosage of 8.1 kg/mg/day. After lacosamide trial, 11 patients (42%) had an over 50% reduction of seizures. Six patients (23%) had lacosamide-related adverse events. The percentage of patients on concomitant SCBs was higher among non-responders (10 of 15, 67%) than among responders (6 of 11, 55%). Patients taking concomitant SCBs had a higher ratio of adverse effects (5 of 16, 31%) than their counterparts (1 of 10, 10%).
Conclusion: Lacosamide is an effective and tolerable antiepileptic drug in adolescents with LGS. Concomitant SCB use may lead to less effective treatment and more adverse events.
목차
Introduction
Materials and Methods
Results
Discussion
References
해당간행물 수록 논문
- The Genetic Relationship between Paroxysmal Movement Disorders and Epilepsy
- Efficacy and Safety of Lacosamide in Adolescents with Lennox-Gastaut Syndrome
- A Short Editorial Offering Congratulations to the Journal
- De Novo SCN8A Pathogenic Variant (c.5630A>G; p.Asn1877Ser) Presenting with a Relatively Mild Phenotype
- Effects of Prenatal Drug Exposure on Children’s Working Memory: A Systematic Review
- Prognostic Factors of Patients with Postinfantile Epilepsy and Multiple Independent Spike Foci on Electroencephalography
- Devastating Sinus Headache Treated with Surgical Drainage in an Adolescent Male
- Salmonella Encephalopathy Treated with Early Use of Intravenous Immunoglobulin and Dexamethasone
- Short Course and Early Switch of Vigabatrin for Infantile spasms
- Factitious Seizures and Limb Paralysis in Munchausen Syndrome
참고문헌
관련논문
의약학 > 소아과학분야 NEW
- Acute Necrotizing Encephalopathy in Children with COVID-19 Accompanied by Multisystem Inflammatory Syndrome
- A Case of Cerebellar Infarction While Swimming in a Child Diagnosed by Ataxia and Gait Disturbance
- Profound Biotinidase Deficiency: A Rare but Treatable Inborn Error of Metabolism in a Neonate with Recurrent Seizures
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!