학술논문
CSⅡ 약침의 Sprague-Dawley Rats에 대한 단회 근육투여 독성시험
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- 영문명
- Single Intramuscular Dose Toxicity Study of CSⅡ-YAKCHIM in Sprague-Dawley Rats
- 발행기관
- 임상약침학회
- 저자명
- 김수경(Su-Kyeong Kim) 정철(Chul Jung)
- 간행물 정보
- 『임상약침학회학회지』대한면역약침학회지 제4권 제1호, 1~7쪽, 전체 7쪽
- 주제분류
- 의약학 > 한의학
- 파일형태
- 발행일자
- 2015.06.30
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국문 초록
영문 초록
Objectives : CSⅡ-YAKCHIM was developed to reduce pain in traditional Korean medicine. However, the safety of CSⅡ-YAKCHIM has not been studies. In the present study, single intramuscular dose toxicity study of CSⅡ-YAKCHIM was performed in 6-week old male and female Sprague-Dawley (SD) rats.
Methods : Test groups consisted of one dosing group at a dose of 1.0 mL/animal and one control group (saline), and 5 males and 5 females were assigned to each group. All animals were monitored for clinical signs and body weight changes during the 14-day observation period after administration. They were subjected to gross necropsy at the end of the observation period. At necropsy, necropsy findings and local tolerance test at the injection site were conducted.
Results : All animals in the 1.0 mL/animal group survived the duration of the study. No CSⅡ-YAKCHIM-related effects were evident in clinical signs and body weights in any animal in the 1.0 mL/animal group. At scheduled necropsy, multiple yellow cysts were observed at the injection sites (thigh) of all males and females in the test substance groups. As a result of local tolerance test, there were cysts at the injection sites of all animals that were found with gross findings.
Conclusions : Based on the results of the single intramuscular injection in SD rats, the approximate lethal dose of the CSⅡ-YAKCHIM was considered to be greater than 1.0 mL/animal in male and female rats under the conditions of this study.
목차
Ⅰ. 서 론
Ⅱ. 재료 및 방법
Ⅲ. 결과 및 고찰
Ⅳ. 고 찰
Ⅴ. 결 론
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