CSⅡ 약침의 마우스를 이용한 소핵시험

• 영문명: In Vivo Micronucleus Test of CSⅡ-YAKCHIM in Mice
• 발행기관: 임상약침학회
• 저자명: 이마성(Ma-Seong Lee) 정진호(Jin-Ho Jeong)
• 간행물 정보: 『임상약침학회학회지』대한면역약침학회지 제4권 제1호, 19~24쪽, 전체 6쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2015.06.30

영문 초록

Objectives : This study was designed to determine the potential of CSⅡ-YAKCHIM, manufactured from Brassicae Semen, Raphani Semen, Persicae Semen, and Carthami Fructus extracts, to induce micronuclei in bone marrow cells of mice when the CSⅡ-YAKCHIM was dosed once to ICR mice by intramuscular. Methods : Each of the groups consisted of three doses of CSⅡ-YAKCHIM (0.05, 0.1, and 0.2 mL/animal), positive control (Mitomycin C), and negative control (normal saline). The time to harvest bone marrow cells for the main study was 24 hours. Results : The incidence of micronucleated polychromatic erythrocyte (MNPCE) among polychromatic erythrocyte(PCE) was not significantly increased in the CSⅡ-YAKCHIM-treated groups. Also, the ratio of PCE among total erythrocyte of the CSⅡ-YAKCHIM-treated groups was not significantly different when compared to that of the negative control group. Conclusions : Based on these results, CSⅡ-YAKCHIM did not have any potential to induce micronuclei formation in bone marrow cells of mice under the conditions of this study.

목차

Ⅰ. 서 론

Ⅱ. 재료 및 방법

Ⅲ. 결 과

Ⅳ. 고찰 및 결론

참고문헌

키워드

CSⅡ-YAKCHIM pharmacopuncture toxicity micronucleus test Brassicae Semen Raphani Semen Persicae Semen Carthami Fructus