파킨슨병 치매와 루이소체 치매 환자에서 인지기능과 보호자 부담의 차이점

• 영문명: Differences in the Cognitive Function and Caregiver Burden between the Patients with Parkinson’s Disease Dementia and Dementia with Lewy Bodies
• 발행기관: 대한노인정신의학회
• 저자명: 이지홍(Jihong Lee) 박경련(Kyung Ryun Park) 신윤정(Yoon Jung Shin) 김현숙(Hyun Sook Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제24권 제1호, 42~48쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2020.04.30

영문 초록

Objective: This study aimed to identify the clinical characteristics for differential diagnosis of Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) by analyzing the differences in cognitive function and caregiver burden between the patient groups. Methods: We conducted a retrospective cross-sectional study with idiopathic Parkinson’s disease patients and DLB patients. Differences in cognitive function were measured using the standardized neuropsychological test battery (Seoul Neuropsychological Screening Battery-II). Differences in the caregiver burden were measured by the Neuropsychiatric Inventory-Questionnaire (NPIQ) for behavioral psychological symptoms of dementia (BPSD) and Korean-Instrumental Activities of Daily living (K-IADL) for daily living activities. For statistical analysis, chi-square test and multivariate analysis of variance and binary logistic regression and correlation analysis were conducted using SPSS 22. Results: Nine Parkinson’s disease-Normal cognition (PD-NC), 25 Parkinson’s disease-mild cognitive impairment (PD-MCI), 20 PDD and 11 DLB patients were included. Compared with PDD and DLB, attentional deficit correlated more strongly with DLB, but language dysfunction showed more correlation with PDD. Caregiver burden correlated more strongly with DLB than PDD. Delusion and aberrant motor behaviors of NPI-Q and taking medicine of K-IADL were strongly related with the caregiver burden of both PDD and DLB. Conclusion: This study identified that neuropsychological profile and caregiver burden in comparison of BPSD and ADL can contribute to the differential diagnosis of PDD and DLB.

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키워드

Parkinson’s disease dementia Dementia with Lewy bodies Cognitive function Caregiver burden Behavioral psychological symptoms of dementia Activities of daily living