대사 기반 약물상호작용 연구의 최신 경향

• 영문명: Recent Trends in Drug Interaction Studies based on Drug Metabolism
• 발행기관: 대한약학회
• 저자명: 이진석(Jinseok Lee) 안성훈(Sung-Hoon Ahn)
• 간행물 정보: 『약학회지』제64권 제1호(2020년), 8~20쪽, 전체 13쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2020.02.29

영문 초록

In pharmacotherapy, drugs are often taken with other drugs to overcome the disease. Due to an increase in the elderly population and chronic diseases, the combinational co-administering method of drugs is increasing, and the importance of drug interaction evaluation for drug development and clinical application is also increasing. In the case of combination therapy, co-administration of drug may occur drug-drug interactions due to the competition of endogenous proteins such as drug transporter, drug metabolic enzyme, and plasma protein, including direct physicochemical interactions of drugs. Drug metabolism-based drug interactions are representative of drug-drug interactions in clinical cases. Drug metabolism mostly occurs in the liver by cytochrome P450s as representative drug metabolic enzymes. In addition, phase 2 metabolic enzymes such as glucuronidases and sulfotransferases also have a significant effect on metabolism-based drug interactions. Drug-drug interactions can affect drug efficacy and side effects, and in some cases can be life threatening or cause serious side effects. The combination use of drugs is required to be aware of the potential interactions that may occur with co-administration in order to use the drug safely. Therefore, the pharmacist as an expert in medicine must have the relevant knowledge and ability to cope with problems as needed. In this approach, we introduced the recent research trends on drug interactions that can occur based on the metabolism of drugs among these drug interactions, and discussed clinical significance of drug-drug interactions.

목차

서 론(Introduction)

1. 약력학적/약동학적 상호작용

2. 약물대사효소

3. 대사효소 기반의 약물상호작용

4. 약물상호작용에 관한 임상적 의의

결 론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

Drug-drug interaction drug metabolism pharmacokinetics drug metabolic enzyme