Prophylactic efficacy of probiotics on travelers’ diarrhea: an adaptive meta-analysis of randomized controlled trials

• 발행기관: 한국역학회
• 저자명: Jong-Myon Bae
• 간행물 정보: 『Epidemiology and Health』40, 1~4쪽, 전체 4쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2018.01.01

영문 초록

OBJECTIVES: The 2017 guideline for the prevention of travelers’ diarrhea (TD) by the International Society of Travel Medicine suggested that ‘there is insufficient evidence to recommend the use of commercially available prebiotics or probiotics to prevent or treat TD.’ However, a meta-analysis published in 2007 reported significant efficacy of probiotics in the prevention of TD (summary relative risk [sRR], 0.85, 95% confidence interval [CI], 0.79 to 0.91). This study aimed to synthesize the efficacy of probiotics on TD by updating the meta-analysis of double-blind, placebo-controlled, randomized human trials. METHODS: The search process was conducted by the adaptive meta-analysis method using the ‘cited by’ and ‘similar articles’ options provided by PubMed. The inclusion criteria were double-blind, placebo-controlled, randomized human trials with hypotheses of probiotics as intervention and TD as an outcome. The adaptive meta-analysis was conducted using Stata software using the csi, metan, metafunnel, and metabias options. RESULTS: Eleven articles were selected for the meta-analysis. The sRR was 0.85 (95% CI, 0.79 to 0.91) and showed statistical significance. There was no heterogeneity (I-squared=28.4%) and no publication bias. CONCLUSIONS: Probiotics showed statistically significant efficacy in the prevention of TD.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

CONFLICT OF INTEREST

SUPPLEMENTARY MATERIALS

ORCID

REFERENCES

키워드

Probiotics Diarrhea Randomized controlled trials Meta-analysis