학술논문
A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran
이용수 2
- 영문명
- 발행기관
- 한국역학회
- 저자명
- Masoud Foroutan Ali Rostami Hamidreza Majidiani Seyed Mohammad Riahi Sasan Khazaei Milad Badri Elham Yousefi
- 간행물 정보
- 『Epidemiology and Health』40, 1~8쪽, 전체 8쪽
- 주제분류
- 의약학 > 면역학
- 파일형태
- 발행일자
- 2018.01.01
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국문 초록
영문 초록
OBJECTIVES: Toxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran.
METHODS: We searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied.
RESULTS: A total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against T. gondii infection than healthy individuals.
CONCLUSIONS: The current study revealed a high prevalence of T. gondii infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and T. gondii can cause serious clinical complications, we recommend that periodic screenings for T. gondii infection should be incorporated into the routine clinical care of these patients.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
ACKNOWLEDGEMENTS
CONFLICT OF INTEREST
SUPPLYMENTARY MATERIALS
ORCID
REFERENCES
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