Asymptomatic Middle East Respiratory Syndrome coronavirus infection using a serologic survey in Korea

• 발행기관: 한국역학회
• 저자명: Yeong-Jun Song Jeong-Sun Yang Hee Jung Yoon Hae-Sung Nam Soon Young Lee Hae-Kwan Cheong Woo-Jung Park Sung Han Park Bo Youl Choi Sung Soon Kim Moran Ki
• 간행물 정보: 『Epidemiology and Health』40, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2018.01.01

영문 초록

OBJECTIVES: The rates of asymptomatic infection with Middle East Respiratory Syndrome (MERS) coronavirus vary. A serologic study was conducted to determine the asymptomatic MERS infection rate in healthcare workers and non-healthcare workers by exposure status. METHODS: Study participants were selected from contacts of MERS patients based on a priority system in 4 regions strongly affected by the 2015 MERS outbreak. A sero-epidemiological survey was performed in 1,610 contacts (average duration from exposure to test, 4.8 months), and the collected sera were tested using an enzyme-linked immunespecific assay (ELISA), immunofluorescence assay (IFA), and plaque reduction neutralization antibody test (PRNT). Among the 1,610 contacts, there were 7 ELISA-positive cases, of which 1 exhibited positive IFA and PRNT results. RESULTS: The asymptomatic infection rate was 0.060% (95% confidence interval, 0.002 to 0.346). The asymptomatic MERS case was a patient who had been hospitalized with patient zero on the same floor of the hospital at the same time. The case was quarantined at home for 2 weeks after discharge, and had underlying diseases, including hypertension, angina, and degenerative arthritis. CONCLUSIONS: The asymptomatic infection was acquired via healthcare-associated transmission. Thus, it is necessary to extend serologic studies to include inpatient contacts who have no symptoms.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

CONFLICT OF INTEREST

ORCID

키워드

Asymptomatic infection Epidemiology Middle East Respiratory Syndrome coronavirus Nosocomial infections Outbreak Enzyme-linked immunespecific assay