항산화제에 의한 유전자발현 조절에 관한 연구

• 영문명: Study on the Gene Expression by Antioxidant
• 발행기관: 한국산업기술융합학회(구. 산업기술교육훈련학회)
• 저자명: 정성오(Sung Oh Chung)
• 간행물 정보: 『산업기술연구논문지』산업기술교육훈련논문지 제19권 3호, 113~118쪽, 전체 6쪽
• 주제분류: 공학 > 공학일반
• 파일형태: PDF
• 발행일자: 2014.09.30

영문 초록

Ascorbic acid is a natural confound that is commonly biosynthesized in many animals except primates, guinea pigs, and some birds and possess an unusually high antioxidant activity. The aim of the present study was to investigate whether ascorbic acid could have anti-inflammtory effect in cells. In order to know whether the ascorbic acid would have the suppressive effect on the inflammatory mediators or cytokines gene expression. The levels of interleukin—6QL-6)， tumor necrosis factor(TNF-a), cyclooxygenase-2(COX-2), RANTES, and inducible nitric oxide synthase(iNOS) expression were examined in lipopolysaccaride(LPS) - stimulated RAW 264.7 cells in the presence or absence of ascorbic acid treatment. LPS increased these genes expression in RAW264.7 cells. It was found that this increase was suppressed by ascorbic acid pre-treatment in LPS-stimulated RAW 264.7 cells. Ascorbic acid also suppressed reactive oxygen species(ROS) or reactive nitrogen species(RNS) production in LPS-stimulated RAW 264.7 cells. Therefore, these observations suggest that ascorbic acid can function as a regulator on the gene expression level.

목차

ᅵ. 서 론

II. 실험재료 및 방법

III. 실험결과 및 고찰

IV. 결 론

참고문헌

키워드

Ascorbic Asid(아스코르브산) Antioxidant(항산화제) Radical(라디칼) Gene Expression(유전자발현) Immune Regulation(면역조절)