학술논문
Retinal Protective Effects of Resveratrol via Modulation of Nitric Oxide Synthase on Oxygen-induced Retinopathy
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- 영문명
- 발행기관
- 대한안과학회
- 저자명
- Woo Taek Kim Eok Soo Suh
- 간행물 정보
- 『The Korean Journal of Ophthalmology』Vol.24 No.2, 108~118쪽, 전체 11쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2010.04.30
4,120원
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국문 초록
영문 초록
Purpose: Retinopathy of prematurity (ROP) is one of the leading causes of blindness, with retinal detachment occurring due to oxygen toxicity in preterm infants. Recently, advances in neonatal care have led to improved survival
rates for preterm infants, and ROP has increased in incidence. In the present study, we aimed to determine
whether or not resveratrol exhibits protective effects in an animal model of ROP and in primary retinal cell cultures
of neonatal rat via nitric oxide (NO)-modulating actions using western blotting and real-time PCR with inducible
nitric oxide synthase (iNOS), endothelial NOS (eNOS) and neuronal NOS (nNOS) antibodies and mRNAs.
Methods: In an in vivo oxygen-induced retinopathy (OIR) model, cyclic hyperoxia was induced with 80% O2 for one
day and 21% O2 for one day from P1 to P14 in newborn Sprague-Dawley (SD) rats. Resveratrol was injected intravitreally for seven days and rats were sacrificed at P21. In vitro OIR primary retinal cell culture was performed
using P0-2 SD rats. Hyperoxia injuries were induced through 100% O2 exposure for six hours. Western blotting
and real-time PCR using iNOS, eNOS, nNOS antibodies and primers were performed in the rat model of ROP
and the dispersed retinal cell culture.
Results: In both in vivo and in vitro OIR, the expression of iNOS antibody and mRNA was increased and of eNOS
and nNOS were reduced in the resveratrol-treated group.
Conclusions: In conclusion, resveratrol appeared to exert retinal protective effects via modulation of NO-mediated
mechanism in in vivo and in vitro OIR models.
목차
Materials and Methods
Results
Discussion
Conflict of Interest
Acknowledgement
References
해당간행물 수록 논문
- Clinical Applications of Photopic Negative Response (PhNR) for the Treatment of Glaucoma and Diabetic Retinopathy
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- Protective Effect of Catechin on Apoptosis of the Lens Epithelium in Rats with N-methyl-N-nitrosourea-induced Cataracts
- Combined Ethylenediaminetetraacetic Acid Chelation, Phototherapeutic Keratectomy and Amniotic Membrane Transplantation for Treatment of Band Keratopathy
- Retinal Protective Effects of Resveratrol via Modulation of Nitric Oxide Synthase on Oxygen-induced Retinopathy
- Assessment of Quality of Life and Depression in Korean Patients with Graves’ Ophthalmopathy
- Traumatic Optic Neuropathy Accompanying Orbital Grease Gun Injury
- Clinical Progress in Impending Central Retinal Vein Occlusion
- Case of Bilateral Retinal Neovascularization Associated with Chronic Idiopathic Myelofibrosis
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- A Case of Optic Neuritis Complicating Herpes Zoster Ophthalmicus in a Child
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