학술논문
Protective Effect of Catechin on Apoptosis of the Lens Epithelium in Rats with N-methyl-N-nitrosourea-induced Cataracts
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- 영문명
- 발행기관
- 대한안과학회
- 저자명
- Sung Min Lee Il-Gyu Ko Sung-Eun Kim Dong Hee Kim Byung Nam Kang
- 간행물 정보
- 『The Korean Journal of Ophthalmology』Vol.24 No.2, 101~107쪽, 전체 7쪽
- 주제분류
- 의약학 > 기타의약학
- 파일형태
- 발행일자
- 2010.04.30
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국문 초록
영문 초록
Purpose: To investigate the effect of catechin on apoptotic cell death in the lens epithelium of rats with cataract.
Methods: Cataract was induced by intraperitoneal injection of 100 mg/kg N-methyl-N-nitrosourea (MNU) to ten
day-old Sprague-Dawley rats. The neonatal rats were randomly divided into five groups (n=15 in each group): a
control group, and four cataract-induction groups, treated with either 0, 50, 100, 200 mg/kg catechin. We performed
slit-lamp biomicroscopic analysis, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling
(TUNEL) assay, Western-blot for Bcl-2 and Bax, and immunohistochemistry for caspase-3.
Results: Apoptotic cell death in lens epithelial cells that increased following cataract formation in rats was suppressed
by cathechin.
Conclusions: Catechin inhibited cataract-induced apoptotic cell death in the lens epithelium and may prove useful
for the prevention of cataract progression.
목차
Materials and Methods
Results
Discussion
Conflict of Interest
References
해당간행물 수록 논문
- Clinical Applications of Photopic Negative Response (PhNR) for the Treatment of Glaucoma and Diabetic Retinopathy
- Case Report of Acremonium Intraocular Infection after Cataract Extraction
- The Short Term Effects of a Single Limbal Relaxing Incision Combined with Clear Corneal Incision
- Protective Effect of Catechin on Apoptosis of the Lens Epithelium in Rats with N-methyl-N-nitrosourea-induced Cataracts
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- Assessment of Quality of Life and Depression in Korean Patients with Graves’ Ophthalmopathy
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- A Comparison of the Clinical Characteristics of Intermittent Exotropia in Children and Adults
- A Case of Optic Neuritis Complicating Herpes Zoster Ophthalmicus in a Child
- Metastatic Esophageal Squamous Cell Carcinoma to the Orbit and Periorbit Masquerading as Periorbital Abscess
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