Clinical Applications of Photopic Negative Response (PhNR) for the Treatment of Glaucoma and Diabetic Retinopathy

• 발행기관: 대한안과학회
• 저자명: Hoon Dong Kim Joo Youn Park Young-Hoon Ohn
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.24 No.2, 89~95쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.04.30

영문 초록

Purpose: To determine the clinical utility of using photopic negative response (PhNR) by comparing the parameters for normal, primary open angle glaucoma (POAG) and diabetic retinopathy (DR). Methods: Electroretinography (UTAS E-3000) was performed in 12 normal, 12 POAG, and 12 DR subjects. Amplitudes and implicit times for PhNR were compared among the three groups. The mean deviation (MD) and pattern standard deviation (PSD) were evaluated using standard automated perimetry (SAP). The mean retinal nerve fiber layer (RNFL) thickness and cup-disc ratio were measured using optical coherence tomography. Results: The a-waves and b-waves were not different among the three groups. However, compared to normal subjects, the PhNR amplitudes were reduced, and the PhNR implicit times were prolonged in the POAG and DR patients (p<0.001, p<0.001). The MD and RNFL thickness were correlated with the amplitudes and implicit times for the PhNR. Conclusions: PhNR may be useful for the detection of inner retinal dysfunction, which is seen in patients who have glaucoma or diabetic retinopathy.

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Conflict of Interest

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키워드

Diabetic retinopathy Electroretinography Glaucoma Photopic negative response