생화학적 표지자을 이용한 근교계 랫드의 유전적 MONITORING

• 영문명: The genetic monitoring of inbred strains of rat through biochemical approach
• 발행기관: 한국예방수의학회
• 저자명: 김용준(Yong Joon KIM) 현병화(, Byeong Hwa HYUN) 김원용(Won Yong KIM) 오구택(Goo Taek OH) 김환묵(Hwan Mook KIM) 최재윤(Jae Yoon CHOI)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.14, No.3, 301~313쪽, 전체 13쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 1990.11.30

영문 초록

A genetic monitoring technique to examine the genetic authenticity of inbred strains of rat was developed and established through biochemical approaches. Four inbred strains, F344/N, LEW /Sea, SHR /Crj and WKYO, were monitored genetically using electrophoresis techniques such as polyacrylamide gel eletrophoresis(PAGE) or cellulose acetate membrane electrophoresis. Results from the present study are as follows; It is very efficient and useful to identify inbred strains of rat for the detection of gene loci of biochemical markers as the genetic monitoring technique. Twenty-three biochemical markers were examined for their gene loci to apply to genetic monitoring, but only a few markers are enough to monitor genetically rat strains for the most case. For genetic monitoring of gene loci which are variable in each substrain, a detection method of major histocompatibility complex (MHC) must be applied together.

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키워드

Genetic monitaring Inbred strain Rat