항체-약물 중합체의 시장 개발 동향 및 신규 플랫폼

• 영문명: Market Trends of antibody-drug conjugate and its new platform technologies
• 발행기관: 대한약학회
• 저자명: 신석호(Seok Ho Shin) 박민호(Min Ho Park) 변진주(Jin Ju Byeon) 이병일(Byeong ill Lee) 박유리(Yuri Park) 최장미(Jangmi Choi) 김나혜(Nahye Kim) 신영근(Young Geun Shin)
• 간행물 정보: 『약학회지』제62권 제3호(2018년), 158~170쪽, 전체 13쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.06.30

영문 초록

The antibody-drug conjugate (ADC) is one of the most rapidly growing next generation antibody therapies used in oncology, autoimmunity and chronic inflammatory diseases. ADC is consisted of monoclonal antibody conjugated via chemical linker with highly cytotoxic small molecules, called payloads. Due to the rising prevalence of cancer and population aging, there is a consistent unmet needs on novel therapeutics for patients where the traditional antibody therapy does not work. With the successful market settlement of FDA-approved Adcetris？？ and Kadcyla？？, global pharmaceutical companies have put their resources for development of this innovative drug class. There are still some drawbacks in this class of drug including linker stability and heterogenous drug antibody ratio (DAR) profile. However new platform technologies are making progress to overcome these problems and further investment will drive growth in the next generation antibody therapies market. In this manuscript, we review the market drivers and restraints and introduce four approved ADCs. We then mainly discuss the important aspects considered while developing ADCs (cytotoxic drug, linker, DAR) and ADC platforms widely used in the industries.

목차

Abstract

서론(Introduction)

결과 및 고찰(Results and Discussion)

결론(Conclusion)

References

키워드

Antibody-drug conjugate linker chemistry next generation biotherapeutics ADC platform