관동화에서 유래한 투실라고논과 4,5-dicaffeoylquinic acid methyl ester가 인간 기도 상피세포에서 MUC5AC 뮤신의 유전자 발현 및 생성에 미치는 영향

• 영문명: Effects of Natural products including Tussilagonone on gene Expression and Production of MUC5AC Mucin from human airway Epithelial Cells
• 발행기관: 대한약학회
• 저자명: 이현재(Hyun Jae Lee)
• 간행물 정보: 『약학회지』제62권 제3호(2018년), 145~152쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.06.30

영문 초록

We investigated whether tussilagonone or 4,5-dicaffeoylquinic acid methyl ester (DQME) affects airway MUC5AC mucin gene expression and production induced by phorbol 12-myristate 13-acetate (PMA) or epidermal growth factor (EGF) from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with PMA or EGF for 24h. The two compounds inhibited the gene expression and production of MUC5AC mucin from NCI-H292 cells. This result suggests that tussilagonone and DQME can inhibit the production and gene expression of mucin induced by PMA or EGF, through directly acting on airway epithelial cells.

목차

Abstract

실험 방법(Experimental Methods)

실험 결과(Results)

고찰(Discussion)

References

키워드

airway mucin tussilagonone