인지기능 저하 노인에서 베타아밀로이드 양전자방출단층촬영의 효용성에 대한 증례군 보고 및 고찰

• 영문명: The Clinical Usefulness of Beta-Amyloid Positron Emission Tomography Imaging in the Elderly Patients : Case Series & Brief Review
• 발행기관: 대한노인정신의학회
• 저자명: 오지훈(Ji Hoon Oh) 나세정(Sae Jung Na) 이승엽(Seung-Yup Lee) 이해국(Hae Kook Lee) 이경욱(Kyoung-Uk Lee) 권용실(Yong-Sil Kweon) 안류연(Ryu Yeon Ahn) 이성용(Sung Yong Lee) 이정태(Chung Tai Lee)
• 간행물 정보: 『노인정신의학』노인정신의학 제20권 제1호, 38~44쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2016.04.30

영문 초록

The aim was to evaluate the diagnostic utility of beta-amyloid positron emission tomography (PET) in elderly patients with cog-nitive impairment in the clinical setting. Five subjects underwent beta-amyloid PET imaging to explore the cerebral beta-amyloid deposition. The two male patients with minor neurocognitive disorder due to Alzheimer’s disease, who displayed similar degree of cognitive impairment and medial temporal atrophy but different in apolipoprotein E4 status, both showed negative for beta-amyloid PET. On the other hand, a female major neurocognitive disorder due to probable Alzheimer’s disease patient was tested positive for beta-amyloid PET, with increased beta-amyloid density in frontal and parietal lobes. Beta-amyloid PET was also used for the dif-ferential diagnosis of neurocognitive disorder from other psychiatric disorders in two elderly patients. The results were negative but assisted the diagnositic confirmation. A female patient was determined to be a case of late-onset schizophrenia and a male patient was determined as delirium due to minor traumatic brain injury, persistent. Beta-amyloid PET imaging was able to demonstrate ce-rebral beta-amyloid deposition in major neurocognitive disorder due to probable Alzheimer’s disease in visual scale. However, fur-ther studies are needed for its clinical utility in the minor neurocognitive disorders. Moreover, beta-amyloid PET imaging may pro-vide additional information in diagnosing primary psychiatric disorders with new onset in the old age.

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키워드

Alzheimer disease Neurocognitive disorders Beta-amyloid protein Positron-emission tomography Late onset disorders 알츠하이머병 신경인지장애 베타아밀로이드 단백질 양전자방출단층촬영 만발성장애.