Increased Th1 cytokine secretion by chiisanogenin and chiisanoside isolated from Acanthopanax chiisanensis

• 발행기관: 대한약학회
• 저자명: Chang Eui Hong Seung Yeon Han Hwan Gyu Kim Su Yun Lyu
• 간행물 정보: 『약학회지』제61권 제6호(2017년), 344~349쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.12.30

영문 초록

Acanthopanax species (Araliaceae) is used traditionally in Korea, Japan, and China, and is known for its ginsenglike activities and among them, Acanthopanax chiisanensis Nakai is one of the most abundant. In this study, we investigated the effects of chiisanoside and chiisanogenin isolated from A. chiisanensis on the secretion of interleukin (IL)-2, IL-12, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) by human lymphocyte cell line U937. Our results show an increase in Th1 cytokine (IL-2, IL-12, TNF-α, and IFN-γ) secretion which suggests that chiisanogenin and chiisanoside from A. chiisanensis may influence the immune response towards a predominance of Th1 cytokines in the immune system. Further studies on Th2 cytokine secretion may be needed to confirm this conclusion.

목차

Abstract

Introduction

Experiment methods

Experimental results

Discussion

Conclusion

References

키워드

Acanthopanax chiisanensis Chiisanogenin Chiisanoside Immuno-stiumlation