RAW 264.7세포에 감염시킨 Salmonella gallinarum에 대한 나트륨염 복합조성물의 항균효과

• 영문명: Antibacterial effect of sodium salt mixture against Salmonella gallinarum infection in RAW 264.7 cells
• 발행기관: 한국예방수의학회
• 저자명: 임정주(Jeong Ju Lim) 차춘남(Chun Nam Cha) 김대근(Dae Geun Kim) 이진주(Jin Ju Lee) 이여은(Yeo Eun Lee) 손송이(Song Ee Son) 김석(Suk Kim) 이후장(Hu Jang Lee)
• 간행물 정보: 『Korean Journal of Veterinary Public Health』Vol.35, No.3, 189~193쪽, 전체 5쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2011.09.30

영문 초록

The present study was investigated the antibacterial effect of several sodium salts and the sodium salt mixture composed with sodium chlorate, sodium azide and sodium cyanide on Salmonella gallinarum (S. gallinarum) infection in murine derived macrophage RAW 264.7 cells. In the infection assay of S. gallinarum in macrophage cells pretreated with 15 mM sodium chlorate, 0.3 mM sodium cyanide, 0.3 mM sodium azide and the sodium salt mixture (15 mM sodium chlorate, 0.3 mM sodium cyanide, 0.3 mM sodium azide), respectively, the numbers of S. gallinarum in all treated-groups tended to decrease in the process of time after treatment, but the group treated with sodium cyanide was no significant difference compared with control. After 24 hours of treatment, the number of S. gallinarum in sodium azide (p<0.05), sodium chlorate (p<0.001) and the sodium salt mixture (p<0.001) treated-group was significantly decreased compared with control, and that in the sodium salt mixture treated-group was decreased the higher than all groups. The results of this study demonstrated that the sodium salt mixture composed with sodium chlorate, sodium azide and sodium cyanide, has the antimicrobial activity for S. gallinarum and may be beneficial on the control of intracellular pathogens.

키워드

Antibacterial Effect odium Chlorate odium Azide odium Cyanide . gallinarum