인삼 추출물의 치매유도 동물모델에 대한 기억력 개선효과

• 영문명: Effect of Ginseng Extract on Memory Improvement in the Amnesic Mice
• 발행기관: 한국산업기술융합학회(구. 산업기술교육훈련학회)
• 저자명: 김세찬(Se-Chan Kim)
• 간행물 정보: 『산업기술연구논문지』산업기술교육훈련논문지 제22권 2호, 55~60쪽, 전체 6쪽
• 주제분류: 공학 > 공학일반
• 파일형태: PDF
• 발행일자: 2017.06.30

영문 초록

This study investigated the effect of black ginseng on the learning and memory impairment induced by scopolamine (SCOP, 2 mg/kg) compared with white, red, and black ginseng (WGE, RGE, BGE, 200 mg/kg). Tacrine (10 mg/kg) was used as a positive control. Ginseng-treated groups significantly reversed scopolamine-induced memory impairment in passive avoidance test and also reduced escape latency in training trials of the Morris water maze test. The increased AChE activity induced by SCOP was significantly inhibited by oral treatment of WGE and RGE extract (p<0.001). SCOP administration did not change ChAT activity, but RGE and BGE significantly increased ChAT activity (p<0.05). These results suggest that black ginseng showed the potential cognitive-enhancing activity by regulating cholinergic marker protein.

목차

Ⅰ. 서 론

Ⅱ. 재료 및 방법

Ⅲ. 결과 및 고찰

Ⅳ. 결 론

키워드

Black Gnseng(흑삼) Passive Avoidance Test(수동회피반응시험) Morris Water Maze Test(수중미로실험) Scopolamine(스코폴라민) Acetylcholinesterase(아테틸콜린에스테라제) Choline Acetyltransferase(콜린 아스틸트랜스페라제)