알츠하이머병에서 우울 증상과 고혈압의 관계

• 영문명: Hypertension is Associated with Depressive Symptoms in Alzheimer’s Disease
• 발행기관: 대한노인정신의학회
• 저자명: 김규동(Kyu-Dong Kim) 이승엽(Seung-Yup Lee) 이해국(Hae-Kook Lee) 이경욱(Kyoung-Uk Lee) 권용실( Yong-Sil Kweon) 이정태(Chung-Tai Lee)
• 간행물 정보: 『노인정신의학』노인정신의학 제21권 제2호, 55~58쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2017.10.30

영문 초록

Objective：To explore the effect of vascular risk factors to the depressive symptom in Alzheimer’s disease (AD). Methods：Retrospective chart reviews were performed for the patients, who underwent comprehensive neuropsychiatric assessment in the geriatric psychiatric clinic in the period between May of 2015 and January of 2017. Patients with moderate to severe stage of AD, neurological comorbidities and major psychiatric disorders were excluded to minimize the confounding factors. Sixty five newly diagnosed early AD patients were included and bisected by the cutoff point of 5 in the short version of the Geriatric Depression Scale. Comparisons were done between two groups for vascular risk factors and other relevant clinic-demographic variables. Binary logistic regression analysis was additionally performed to estimate the effect of hypertension to the depressive symptoms. Results：Among the investigated vascular risk factors, hypertension was associated with depressive symptom in the early AD patients. In the logistic regression, odd ratio of hypertension for depression was 4.34 (95% confidence interval 1.47-12.79). Conclusion：Depressive symptoms in the AD patients were associated with hypertension. Therefore, managing this vascular factor in the middle age may not only decrease the risk for neurovascular disorders, but also provide additional benefits in curtailing depression in AD.

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키워드

Vascular risk factor Hypertension Alzheimer’s disease Depression Neurocognitive disorder