알츠하이머병 환자에서 정신증적 증상과 연관된 좌측 판개부 및좌측 외측 후두회의 피질 두께 변화

• 발행기관: 대한노인정신의학회
• 저자명: 이두형(Doo Hyoung Lee) 김경미(Gyung Mee Kim) 박선철(Seon-Cheol Park) 김태형(Tae Hyung Kim) 최승은(Seung Eun Cho) 정태영(Tae-Yeong Jeong) 이봉주(Bong Ju Lee) 문치웅(Chi Woong Mun) 이정구 (Jung Goo Lee) 김영훈(Young Hoon Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제21권 제2호, 67~74쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2017.10.30

영문 초록

Objective：The aims of this study was to present an association between the presence of psychotic symptoms and cortical thicknesses/subcortical volumes in patients with Alzheimer’s disease (AD). Methods：Fourteen AD patients with psychotic symptoms and 41 without psychotic symptoms underwent 3T MRI scanning. After adjusting the effects of confounding variables, the cortical thicknesses were compared between the AD patients with and without psychotic symptoms in multiple regions, across the continuous cortical surface. In addition, the subcortical volumes were compared with a structure-by-structure manner. Results：AD patients with psychotic symptoms were characterized by significant smaller cortical thickness of left pars opercularis (F=4.67, p=0.02) and left lateral occipital gyrus (F=6.05, p=0.04) rather than those without psychotic symptoms, after adjusting the effects of age and scores on the Stroop test, non-psychotic items of Neuropsychiatry Inventory and Clinical Dementia Rating, triglyceride level and total intracranial volume. However, there were no significant differences in the subcortical volume between the two groups. Conclusion：These results suggest that AD psychosis may reflect more severe deterioration of neuropathologic change in specific brain region.

키워드

Alzheimer’s disease Left lateral occipital gyrus Left pars opercularis Psychotic symptoms