알코올 의존 환자에 있어서 알코올 연관 자극에 의해 유발된 조건화된 생리적 반응에 대한 날트렉손 투여 효과

• 영문명: Effect of Naltrexone on Conditioned Physiological Responses Induced by Alcohol Related Cue in the Alcoholics
• 발행기관: 한국중독정신의학회
• 저자명: 김성곤(Sung-Gon Kim) 송영상(Young-Sang Song) 박제민(Je-Min Park) 김명정(Myung-Jung Kim)
• 간행물 정보: 『중독정신의학』Vol.6, No.1, 3~10쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2002.04.30

영문 초록

Objectives：The effect of naltrexone on conditioned physiological responses induced by alcohol related cue (ARC) was studied. Methods：Entered were 16 hospitalized patients with alcohol dependence who showed ARC-induced increase of alcohol craving for a study using placebo controlled crossover design. Either 50 mg of naltrexone or placebo was given for 7 days followed by 7 days of washout period and 7 days of placebo or naltrexone in a crossover design. Measured were changes of systolic and diastolic blood pressure, mean arterial blood pressure, pulse rate and alcohol craving induced by a neutral and alcohol related cue and the amount of salivation during exposure to the same cues. Results：1) The ARC induced a significant increase in salivation and naltrexone blocked the increase of salivation and alcohol craving. 2) The ARC showed a tendency to increase systolic blood pressure and mean arterial pressure and naltrexone blocked these effects. 3) The ARC and naltrexone did not show any effect on diastolic blood pressure and pulse rate. Conclusion：These results suggest that naltrexone has antagonizing effect on certain ARC-induced conditioned physiological responses.

키워드

Naltrexone Alcohol dependence Conditioned physiological response Salivation