미취학 아동의 양성돌발행동에서 철분보충요법의 효용

• 영문명: Iron Supplement in Paroxysmal Non-epileptic Events in Children
• 발행기관: 대한소아신경학회
• 저자명: 이진선(Jinsun Lee) 최진혁(Jinhyuk Choi) 권혁희(Hyeok Hee Kwon) 강준원(Joon Won Kang)
• 간행물 정보: 『Annals of Child Neurology(구 대한소아신경학회지)』대한소아신경학회지 제25권 제3호, 146~150쪽, 전체 5쪽
• 주제분류: 의약학 > 소아과학
• 파일형태: PDF
• 발행일자: 2017.07.30

영문 초록

Purpose: Paroxysmal non-epileptic event (PNE) is a common seizure-like symptom in children. With regard to therapy, a decrease in iron levels was reported in breathholding spells, but not in other PNEs. The effects of iron supplementation were investigated on various PNEs. Methods: Medical records of patients who visited our clinic with seizure-like symp toms were retrospectively reviewed at Chungnam National University Hospital, from March 2013 to March 2016. Results: A total of 29 patients (65.9%) were boys and 15 (34.1%) were girls. The mean gestational age and birth weight were 39.3 weeks and 3,200 g, respectively. The mean age at the time of visit was 23.5 months. Of the 11 patients who underwent brain imaging, 10 (90.9%) had normal findings and 1 (9.1%) had subdural hemorrhage. An electroencephalogram was performed in 29 patients; 26 of them had normal findings (89.7%), 2 (6.9%) had slow background, and 1 (3.4%) had epileptiform discharges. A total of 31 patients (70.5%) had iron levels lower than 80 µg/dL. Iron supplementation was administered in 4 of the 13 patients with normal iron status and in 21 of the 31 patients with low iron status. A significant improvement in the frequency and severity of symptom was observed in 91.7% of patients who received iron supplementation (P<0.05). Conclusions: Symptoms improved in 80% of patients with PNE, and a higher rate of symptom improvement could be expected with iron supplementation.

키워드

Infant behavior Seizure Iron Children