안지오텐신 전환 효소 유전자 다형성과 알코올 의존

• 영문명: Angiotensin-Converting Enzyme Gene Polymorphism and Alcohol Dependence
• 발행기관: 한국중독정신의학회
• 저자명: 박선희(Sunny Park) 이태경(Tae-Kyung Lee) 이종일(Jong-Il Lee):김종우(Jong-Woo Kim) 이희제(Hee-Jae Lee) 박종득(Jong-Deuk Park) 송지영(Ji-Young Song)
• 간행물 정보: 『중독정신의학』Vol.8, No.2, 75~81쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.09.30

영문 초록

Objective：There is increasing evidence that Renin-Angiotensin System is involved in the pathophysiology of alcoholics. This study was performed to examine the relationship between Renin-Angiotensin System and alcoholics by analyzing polymorphism of Angiotensin converting enzyme (ACE), an compartment of Renin-Angiotensin System. Methods：We examined the frequency of a polymorphism of the ACE gene (located on chromosome 17q23) in groups of patients with alcohol dependence (n=99) compared to healthy control subjects (n=177). ACE genotype was determined by size-analysis of polymerase chain reaction products. Results：No difference was found between the alcohol dependent patients and the controls in genotype and allele frequencies of the ACE I/D polymorphism. Significant difference of FTND score was found among ACE genotype groups in alcohol dependent patients (F=3.657, df=2,96, p= 0.029). Significant difference of impulsiveness of non planning and impulsiveness of motor was found among ACE genotype groups in alcohol dependent patients who started first drinking at 19 years or more (IONP F=6.921, df=2,60, p=0.002；IOM F=3.913, df=2,60, p=0.025). Conclusion：These results do not support an association between polymorphism of ACE gene and alcohol dependence. It is suggested that I/D polymorphism in the ACE gene could be associated with nicotine dependence severity in alcohol dependent patients and with alcohol dependence patients who started first drinking at 19 years or more.impulsiveness in

키워드

Alcohol dependence Angiotensin converting enzyme (ACE) Polymorphism